Solvent Accessible Surface Area (SASA)
Profiling the Protein–Solvent Interface for Insightful Design
Proteins don’t function in isolation — they operate in a dynamic aqueous environment.
Understanding how much of a molecule is exposed to this environment is critical for decoding stability, reactivity, and interaction potential.
At code2fold, we perform Solvent Accessible Surface Area (SASA) analysis to map out the molecular surface with high precision, revealing patterns that drive function and inform design.
🔍 Why SASA Matters
SASA tells us where a molecule is accessible — and where it’s not.
- Is the hydrophobic core intact and shielded from solvent?
- Are binding pockets adequately exposed or occluded?
- How does a mutation shift surface exposure and affect solubility or binding?
These questions are fundamental in:
- Drug design (identifying accessible ligand binding sites)
- Protein engineering (optimizing surface charge or solubility)
- Structural validation (comparing expected vs. observed exposure)
- Mutation impact studies (detecting buried-to-exposed residue shifts)
🧪 What Code2fold Offers
We deliver high-resolution surface accessibility profiles including:
- Per-residue SASA values across the trajectory
- Buried vs. exposed residue classification
- Mutation-induced surface shift mapping
- Overlay with functional motifs or PTMs
- Ligand interaction surface analysis
- Interactive 3D visualizations and custom plots
From structural models to full-length dynamics trajectories — we quantify how your biomolecule meets the environment.
💡 Why Work With Code2fold?
Surface accessibility is more than a number.
It’s a functional signature — and we help you read it.
At code2fold, we blend computational precision with biological relevance to give researchers clear, actionable insights about their system’s solvent interactions.
Whether you’re designing a drug, testing a mutation, or optimizing expression, our SASA analysis will clarify what lies at the surface — and why it matters.
📩 Start Surface Profiling Today
Bring solvent exposure into focus.
Contact code2fold to profile your biomolecular surfaces with precision and purpose.